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The effect of the neuronal clumps varies, Dr. Walsh said.
Laterally, a tendency to form little defined neuronal clumps can be observed.
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Neuronal inclusions are clumps of mutated huntingtin protein fragments that result from having HD.
It should be mentioned here that, Nissl stain would stain mainly the nuclei of neuronal cells and clumps of material surrounding the nuclei.
This was associated by clumping of neuronal processes (appearing as excess eosinophilia) which is indicative of damage to neurons.
Addition of memantine to insulin therapy caused an additional mild improvement in the preservation of the cells, but with persistence of clumping of neuronal processes and widened capillaries in many fields.
Tenascin-C appears as clumps concentrated on neurons and covering neuronal processes connecting widespread groups of cells.
Individuals who are Met carriers are less able to compensate for this BDNF reduction owing to deficient transport of the BDNF preprotein which causes clumping around the nucleus, perhaps leading to neuronal atrophy in response to reduced BDNF levels.
Only in end-stage G93A SOD1 mice the anti-aconitase antiserum also labelled clumps of amorphous material scattered in the cytoplasm of large neuronal cell bodies identifiable as motor neurons (Fig. 5H).
(To learn more about parts of the brain affected in HD, click here.) In both people and mice with HD, the proteins formed from the HD allele tend to clump together and clog up the nucleus by forming aggregations called neuronal inclusions (NI).
Following transfer of small clumps of the outgrowth colonies onto MS5 murine stromal cells, we observed formation of neuronal rosettes from as early as 10 days following co-culture, which were mechanically isolated from day 10 to day 15 of co-culture.
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