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In functional tests of hpg kisspeptin neuron responsiveness, the distribution of kisspeptin immunoreactivity in the OVX+E2-treated hpg ARC was restored to the pattern found in WT mice.
On the other hand, there are "rare" Ostrinia males (3 5%) that possess the ability to respond to a pheromone blend which is not effective for most individuals in the population [15], [40] [41]; moreover, significant differences in olfactory neuron responsiveness have been observed between rare and normal males [42] [43].
The deletion of 16 mouse V1R genes results in altered social behavior and loss of vomeronasal neuron responsiveness to specific pheromones [ 14], and V1R (V1Rb2) specifically responds to the mouse pheromone, 2-heptanone [ 15].
In light of evidence that LPBN-derived CCK is the sole source of CCK terminals within the VMH (Nagai et al., 1987), these data suggest SF1VMH neuron responsiveness to CCK lies in their innervation by CCKLPBN neurons.
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In cultured neurons, the lactate dehydrogenase isoenzyme pattern was not altered by medium glucose level (5.5, 13.4 or 26.8 mmol/l; O'Brien et al., 2007), but Kleman et al. (2008) emphasize the negative effects of high glucose levels on the viability of cultured neurons and neuronal responsiveness to the AMPK (AMP-activated protein kinase) energy signalling system.
In particular, identifying relevant inputs that shape DA neurons' responsiveness to stress is essential and has important implications for future therapeutic advances.
At the neuronal level, repeated or prolonged exposure to a stimulus (adaptation) is classically known to reduce the neurons' responsiveness to the same stimulus.
These DA neurons' responsiveness appears to encode a wide range of novel and reward-related events through a prediction error rule [6] [8].
These dopamine neurons' responsiveness appears to encode a wide range of novel and reward-related events through a prediction error rule [5] [9].
No difference in the neurons' responsiveness to the MAG mutant in comparison to wildtype MAG was observed neither with wildtype nor ngr1/ngr2 double knock-out neurons (Fig. 6D), confirming that the sialic acid binding ability of MAG is not necessary for its inhibitory activity on neurons.
However, in FS neurons, responsiveness to calls appeared to be less strongly modulated by touch at the individual and population levels (p = 0.3303, Figure 5E).
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