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They have abnormal shape of hindbrain neurons, such as curved neuron pattern and uneven cranial ganglia length.
The patient may then deteriorate and have a decreased level of consciousness, a lower motor neuron pattern of weakness and respiratory failure.
After the acute phenomena subsided, she showed evident cognitive impairment, upper motor neuron pattern of weakness in limb muscles, hyperactive deep tendon reflexes, bilateral Babinski sign, dysarthric speech, and spastic gait.
Lower motor neuron pattern leg signs with areflexia, often associated with objective evidence of muscle weakness and myopathic gait, was present in the majority of patients (79%) (Fig. 6).
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The neuron patterns are similar to biological neural nets and are modeled after the human brain (Tulunay et al., 2004a).
The protein helps to guide axons, the long extensions of neurons, in the brain, and the researchers expected that neuron patterns might be affected.
It has been reported that neurotrophins and Trk receptors are involved in almost all stages of nervous system development, such as survival, proliferation, differentiation, migration, axon and dendrite projection, and neuron patterning [ 23, 27- 30].
Beyond that, additional investigations on myriapods are still needed to estimate more confidently the true potential of SL-ir neuron patterns in the arthropod VNC within a phylogenetic-evolutionary framework.
Similarly, in the dopaminergic midbrain system of the mouse, the ratios of expression of several dopaminergic marker genes were cell-type specific, corresponding to the neurons pattern of projection [21].
In order to avoid assigning significance to a N-neuron pattern just because it contains N-1-neuron motifs we incorporate the N-1-neuron statistics into the expectations used to search for N-neuron motifs [ 8].
For comparing the count of quadruplets, we construct random matrices that keep the same not only in-degree and out-degree of uni-directional and bi-directional connections for each neuron but also the count of the 16 different 3-neuron pattern in the whole matrix.
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