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In Drosophila models of AD-HSP, larvae lacking Spastin exhibit abnormal motor neuron morphology and function, and most die as pupae.
Finally, we show that the loss of ptrn-1 function results in defective neurite branching and mislocalization of synaptic vesicles, indicating that it has an important role in neuron morphology and function.
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The complexity of external cues is reflected in part in the remarkable diversity of sensory neuron morphologies and functions.
In our experiments, the low number of T. gondii cysts and the corresponding moderate number of infected neurons suggest that, in addition to the infected cells, other components might alter neuronal morphology and function.
An important aspect of understanding the function of Wnt2 is to determine where at the synapse it functions to regulate presynaptic motor neuron morphology and localization of proteins.
In neurons, the transport functions of microtubules are especially crucial for establishing neuron morphology and maintaining synapses distant from the cell body.
After evaluating mitochondrial morphology and function in neurons cultured at atmospheric, 9, 5 and 2% oxygen, we determined that 9% oxygen was not significantly different than the atmospheric condition and all of our data here focuses on atmospheric, 5 and 2% oxygen conditions.
Recent evidence suggests additional roles of mammalian PUM2 in neurons i.e. for maintaining synapse morphology and function [30], [34].
We found that the overexpression of miR-34a in vitro significantly increases precursor proliferation and influences morphology and function of developing neurons.
Although the morphology and function of the SI antennal-lobe neuron has been thoroughly studied in numerous insect species, the physiology of the neuron itself is largely unexplored.
As both morphology and function can be visualized in large assemblies of neurons, questions of simultaneous activity of neurons within a network can be addressed.
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