Furthermore, the Drosophila CD36 homologue, sensory neuron member protein (Snmp), is essential for optimal Or67d neuronal activation (Benton et al., 2007).
Among the 49 neuronal miRNAs in primary human neurons were members of 3 related genomic clusters; 4 members of the miR-17 cluster on chromosome 13 (miRNAs 17, 19a, 19b, and 20a; Fig. 6A), 3 members of the miR-106a cluster on chromosome X (miRNAs 19b, 20b, and 106a; Fig. 6B) and 2 members of the miR-106b cluster on chromosome 7 (miRNAs 106b and 93; Fig. 6C).
These neurons express members of one of the largest gene families in the mammalian genome, the olfactory receptors (ORs) [ 1].
STMN2 is a neuron specific member of the stathmin family of small regulatory phosphoproteins which control cell profileration and differentiation [ 99].
To determine if this effect was unique to Map2, we measured expression additional neuronal markers in hNP cells differentiated under these conditions: HuC and HuD and neuron-specific members of the ELAV family of RNA-binding proteins (Perrone-Bizzozero and Bolognani, 2002), and ChAT is a marker of cholinergic neurons (Cui and Qiao, 2006).
Cyclic nucleotide gated channels (CNGCs) from olfactory and retinal neurons are members of the S4-containing superfamily of ion channels [ 17, 18] with their unusual stretch of hydrophobic and basic amino acids thought to serve as a transmembrane voltage sensor for channel gating [ 19].
CABP1 is a neuron-specific member of the calmodulin superfamily, and modulates Ca2+-dependent activity of inositol 1, 4, 5-trisphosphate receptors [ 16].
The olfactory C family GPCRs are expressed by the subpopulation of microvillous sensory neurons in the fish's single olfactory organ, distinct from the ciliated sensory neurons which express members of the OR family of odorant receptors [ 25, 27].
In addition, both erythropoietin and its receptor found in the human cerebral cortex, astrocytes, and neurons that are members of a cytokine superfamily mediate diverse functions in nonhematopoietic tissues.
The molecular mechanism underlying this neuronal loss has been greatly facilitated by the phenotypic analysis of nerve growth factor (NGF -dependent sympathetic NGF -dependentg sympatheticmbers of the Bcl-2 family (2).
