The overall downscaling of inhibitory gain shown for SNHL neurons may be associated with various clinical conditions such as epilepsy, tinnitus, and presbycusis that are also characterized by reduced GABAergic gain.
This has clinical significance because sensory neuron receptors may be associated with certain forms of bladder dysfunction.
The increased DA neuron activity may be associated, at least in part, with the 5-HT1B receptor-mediated inhibitiof of VTA GABA release.
Our quantitative analysis of neuron morphology may be used to study various factors that could influence the development and functions of neurons that may be associated to brain disorders such as ASD.
This pattern might be explained by the expression of GbX in neurons that may be associated with the sensory system, as observed in zebrafish Danio rerio (Blank, Wollberg, et al. 2011).
Whilst a fall in neuron numbers seems a common pattern during postnatal development, several authors have nonetheless reported an increase in neuron number, which may be associated with any one of a number of possible processes encapsulating either neurogenesis or late maturation and incomplete differentiation.
Neuronal loss may be associated with normal ageing, though research using different procedures for counting neurons suggests this may have been overestimated[ 12].
Our findings are to our knowledge the first to suggest that the LRRK2-mediated pathway induces mitochondrial dysfunction and loss of cerebellar Purkinje neurons and, subsequently, may be associated with motor coordination deficits in STZ-diabetic rats.
It has been suggested that the decrease in the number of neurons by apoptosis may be associated with trophic factor(s) deprivation (Ambacher et al. 2012) or with the absence or reduction of anti-apoptotic proteins such as B-cell lymphoma 2 (Bcl-2) (Allsopp et al. 1993).
Kirita et al reported that the Na+ current was significantly increased in the root constriction neurons and lumbar radicular pain may be associated with increased excitability of the involved DRG neurons.
