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On the other hand, increasing evidence has shown that there are also direct correlations between source neuron gene expression patterns and projection target specificity [13].
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These induced sensory neurons (iSNs) were electrically active, exhibited distinct sensory neuron morphologies and matched the characteristic gene expression patterns of endogenous sensory neurons, including selective expression of Trk receptors.
Expressed novel retrocopies of neuron-specific genes could alter gene expression patterns on a cell-to-cell basis, either by increasing levels of already expressed genes, or by negative regulatory mechanisms.
It is likely that this variation is used for generating GABAergic neuron subpopulations, which differ in their gene expression patterns and cellular phenotypes.
Despite the high proportion of arrhythmic neurons revealed by SFR recordings, clock gene expression patterns were not grossly disrupted in the SCNs of Kcnma1−/− mice [14].
The abovementioned studies focused on analyzing how the gene expression patterns of source and target neurons are correlated as compared to neurons that are not connected.
We mainly focused on studying how the gene expression patterns in the source neurons are globally related to projection target specificity.
If Jessell and his colleagues can tease out the gene expression patterns that contribute to normal neuron development, there could be vital implications for neurodegenerative disorders and spinal cord injuries.
The gene expression patterns in normal and PD dopaminergic neurons were reported to be gender-specific [ 26, 38].
A treasure trove of gene expression patterns.
Clusters were established by normalized gene expression patterns as shown in gene expression view.
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