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To examine the extent to which these oscillations reflect neuron engagement in distinct local circuit processes that are important for memory, we recorded single cell and local field potential activity from the CA1 region of the hippocampus as rats performed a context-guided odor-reward association task.
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Interestingly, we found clear differences between RR neurons and nonRR neurons in their engagement with the hippocampus.
In Molecular Neurodegeneration, Inoue and coworkers identified a surprising mechanism underlying degeneration in autophagy-deficient neurons, involving the engagement of a phospho-Tau-dependent pathway [ 8].
These data suggest that the CR function of CCKLPBN neurons is predicated upon their engagement of downstream SF1VMH neurons.
Understanding the flexible engagement of neurons into rhythmic circuits allows us to uncover the mechanisms through which single cells contribute to systems level processes.
In neural interface platforms, cultures are often carried out on a flat, open, rigid, and opaque substrate, posing challenges to reflecting the native microenvironment of the brain and precise engagement with neurons.
The functional significance of phase synchronisation lies in the fact that it enables the engagement of target neurons and facilitation of inter-regional interaction with the appropriate phase differences while simultaneously suppressing out of phase neural inputs [12].
A mechanism for this action could involve engagement of the mirror neuron system and its interaction with the limbic system via the insula [70].
The results showed that compared with Naming, the speech act of Requesting elicits additional activation in the fronto-parietal areas of the brain compatible with the engagement of the mirror neuron and theory of mind systems.
Taken together, cell type-specific transcriptional profiling, immunohistochemistry, and a cell type-specific UPR reporter construct indicate engagement of ER-stress pathways selectively in AGRP neurons during energy deficit.
For example, OPHN1 is a neuron-specific mRNA containing uORFs that is translationally upregulated after mGluR engagement and eIF2α phosphorylation and induces LTD.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com