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To realize a nanowire-based neuron device, coupling of nanowires with neurons is essential.
This paper reviews recent theoretical results carried out within the European project, Bioelectronic Olfactory Neuron Device, which provides a first quantitative interpretation of charge transport experiments exploiting static and dynamic electrical properties of several receptors.
With a value of TACC close to the 10 ns allowed by the current ROM technology, the proposed neuron responds within 80 ns, NEUROM is therefore the neuron device proposed in the literature which allows for maximum throughput.
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However, other semiconductor nanowires that can be considered for neuron devices have not yet been investigated.
Analysis of the interfacial structures is thus essential in the design of nanowire-based neuron devices as well as for understanding the signal transfer mechanism.
Many approaches can be considered for the fabrication of nanowire-based neuron devices, including coupling nanowire transistors to neurons [24, 25] and probing neurons with vertical nanowire array [26].
Regardless of the mechanism, the neuron nanowire couples may be advantageous for the development of neuron devices in terms of signal transfer and electronic coupling, since the clefts pose critical problems in relation to signal transfer and electronic coupling strength.
Among these, nanowire-based neuron devices that can monitor or stimulate neurons on a submicron dimension with high sensitivity have been recently noticed for their great potential in neuroscience [3].
In fact, the weak coupling between neuron and devices due to the extracellular cleft is one of the major problems in neuron-electronic interfaces.
From initial demonstrations of electroencephalography-based spelling and single-neuron-based device control, researchers have gone on to use electroencephalographic, intracortical, electrocorticographic, and other brain signals for increasingly complex control of cursors, robotic arms, prostheses, wheelchairs, and other devices.
The majority of the existing knowledge of the tissue response to indwelling brain implants has emerged from the study of neuron recording devices, which can in some cases function successfully in the brain to record neural activity for weeks or months.
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