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The most common biological functions assigned to these gene families included immune defense gene, neuron developments and intercellular communication and transport.
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Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family that plays an important role in neuroplasticity, neuron development, differentiation, and neuronal survival [ 7- 9].
PKCγ is expressed mainly in neuronal tissues, where it plays roles in neuron development and neuropathic signal transduction.
Arlotta, P. et al. Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo.
Galazo, M. J., Emsley, J. G. & Macklis, J. D. Corticothalamic projection neuron development beyond subtype specification: Fog2 and intersectional controls regulate intraclass neuronal diversity.
Damage to primary cilia is now also linked to kidney disease, obesity and even the failure of adult neuron development.
Sun, Y. et al. A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs.
The p75 nerve growth factor receptor mediates survival or death depending on the stage of sensory neuron development.
Chen, J. & Kriegstein, A. R. A GABAergic projection from the zona incerta to cortex promotes cortical neuron development.
Refinement of differentiation protocols to optimize this approach will require deeper understanding of mesDA neuron development.
On the other hand, transfection of a nuclear constitutively active FGFR1 SP-/NLS) was suFGFR1 SP-/NLSnduce neuron development, sometimes producing unusually large neurons28,52.
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