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Additionally, many brain-related processes were induced, such as learning and/or memory, neurogenesis, neuron development and neuron projection (partial list of enriched terms in Fig. 3d and full list Additional file 4: Table S3), indicating that VPA treatment induces plasticity-related biological processes, which are dormant in the adult visual cortex.
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These findings identify Sox6 as a determinant of SNc neuron development and should facilitate the engineering of relevant mDA neurons for cell therapy and disease modeling.
In our study, genes involved in "regulation of neurogenesis" were affected while genes involved in "neuron differentiation", "neuron development" and "axonogenesis" were regulated in Dussaubat et al. (2012).
One of the functions was related to "cytokine response," including "response to hormone stimulus" and "response to inorganic substance," and the other function was related to "neuron function," including "neuron development" and "axonogenesis".
Although CuZnSOD is not required for motor neuron development and function, the motor neurons of the sod1 /– mice have been reported to display mitochondrial dysfunction and axonal degeneration, leading to accelerated age-related muscle atrophy.
Gene Ontology term enrichment analysis revealed that genes up-regulated by Pou3f1 were primarily involved in neural differentiation processes, such as neuron differentiation, neuron development, and axonogenesis, whereas Pou3f1-down-regulated targets were highly enriched in pattern specification and in embryonic morphogenesis.
Most of these breed-specific modules were involved in muscle development, neuron development, and cellular response.
The top gene ontology categories among these under-expressed are specifically related to neuronal function and include neuron projection development, neuron differentiation, and synaptic transmission.
Neuron development, NO signaling, and skeletal development were not among them.
We also found that ENST00000411553 was involved in tissue-related functions such as neuron differentiation, axonogenesis, and neuron development in psychiatric disorders, hormone-mediated signaling pathway in prostate cancer, and regulation of cell migration in breast cancer).
The overrepresentation of "cell morphogenesis", "cell death", "developmental maturation", and "cell-cell signaling", indicates that the shared gene sets are more likely to have implications for brain cell development and degradation, and neuron-to-neuron or glia-to-neuron interaction, respectively.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com