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However, relatively little is known about the molecular mechanisms underlying mdDA neuron development and maintenance.
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BDNF localizes in the hippocampus, hypothalamus, cortex, septum and the adrenergic brain stem nuclei of the brain and participates in neuron development, differentiation and plasticity maintenance throughout life [ 31].
On the other hand, Géranton et al. [ 48], using a tyramide signal amplification- (TSA-) enhanced immunofluorescent staining, demonstrated that phospho-mTOR, phospho-S6 ribosomal protein, and phospho-4E-BP1 are strongly expressed in lamina I/III projection neurons of the dorsal horn, that is, those neurons critically involved in the development and maintenance of chronic pain [ 53].
The neurotrophins are growth factors that promote survival in development and maintenance of neurons.
Finally, another gene of relevance to development and maintenance of neurons, Ntrk2, is 9.8-fold higher expressed in SPF mice.
Glial phagocytosis of superfluous neurons and damaged or aberrant neuronal material is crucial for normal development and maintenance of the CNS.
The development and maintenance of neuronal networks depend on the differentiation of neurons and on the outgrowth and branching of their axons and dendrites.
Although ubiquitously expressed, PPT1 deficiency affects only the development and maintenance of cortical neurons in the nervous system.
The comparisons of expression profiles between human primary and NT2-derived cells revealed miRNAs that might play a role in the development and maintenance of differentiated neurons and astrocytes.
Nurr1 is critical for the development and maintenance of midbrain neurons.
However, a role for Id2 during the development and maintenance of mDA neurons has not been described.
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Justyna Jupowicz-Kozak
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