Lead researcher Dr Guoping Feng said: "Our study demonstrated that Shank3 mutation in mice lead to defects in neuron-neuron communications.
Thy-1 deficiency may affect the release of neurotransmitters and synaptic efficacy, and could contribute to a variety of abnormal neuron-neuron communications.
While the traditional roles of astrocytes have gained experimental support, evidence has accumulated to suggest bidirectional neuron-glia communications [3] and possible participation in neural information processing [4], [5].
Action potential firing leads to the release of ATP [ 177] and adenosine [ 96, 115], which can mediate neuron-glial communications.
Moreover, billions of neurons form trillions of synapses, which are critical points of communications between and amongst neurons.
One of the enigmas in neuroscience is how high-order neural functions emerge from network communications among many neurons of various traits.
During cytokinesis, NG2 cells form cellular processes and synaptic junctions with neurons; some of these synaptic communications, if not all, are eventually passed on to their daughter cells.
The increase in the number of neurons was not recapitulated when GJ intercellular communications were pharmacologically blocked, and this suggested that Cx43 was influencing hNPCs differentiation with a GJ-independent effect.
Through intense study of the neo-cortex, not only the billions of neurons but just as importantly the rules of communications and connectivity, they have been able to build a three dimensional model of the neo-cortex.
It is the massive parallelism of communications and feedback loops that connect our neurons together that make us who we are: self-aware beings with the ability to learn, love, and create.
The neurons comprising the nervous system form a complex network of communications.
