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In addition, the traditional peri-event spike raster or histogram methods have limited the analysis to a single time point when the tone or cue was presented at retention tests (e.g. the time point when the tone is played as time zero for peri-event plots in the single neuron approach).
We confirm the receptors responsible for responses to several compounds using the "empty neuron" approach.
The depolarization block hypotheses are in perfect agreement with our theoretical study, whereas the other potential mechanisms refer to mechanisms beyond a single neuron and, hence, cannot be captured with the single neuron approach presented here.
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But for the single-neuron approach to be useful to a paralyzed patient, it will need to successfully scale up.
But he is no less rooted to a neuron-by-neuron approach that helped him chart the biological genesis of memory in the lowly sea snail, a feat for which he won the Nobel Prize in Physiology or Medicine in 2000.
The population of spiking neurons approach gives rise to a robust dynamic and the possibility to compare with experiments at different spatial scales.
(Note that for both QIF and EIF models, the dynamics are such that neurons approach infinity extremely rapidly. Thus firing can occur even though such a small population of neurons are near threshold).
Single-neuron approach: The way the data are presented, these RGCs could have been measured one at a time.
As the multipolar neurons approach the cortical plate (CP), they enter a bipolar migration stage and re-associate with the glial fibers.
As illustrated in Figure 6a, these stimulus-response functions typically show a compressive response with a steeper slope at low-to-mid contrasts, which flattens as the neurons approach saturation.
This approach is somewhat different from the classic neuron-approach of neurology, looking at what single neurons does.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com