Sentence examples for neuron alterations from inspiring English sources

Whether these changes in muscle cells are causative of ALS or a consequence of motor neuron alterations is not yet clear, but their elucidation is very important, since the understanding of the mechanisms involved in mutant SOD1 toxicity in muscle may facilitate the design of treatments directed toward this specific tissue to treat ALS or at least to delay disease progression.

Finally, motor neuron alterations have also been described in connection with hyperthyroidism [ 34, 39].

Following this research, several groups confirmed that celastrol could indeed improve neuron degenerative alterations [ 7- 9].

Moreover, induction of autophagy and/or inhibition of lysosomal proteolysis enhanced dopaminergic neuron phenotypic alterations, indicating that the defective maturation of autophagosomes into autophagolysosomes partially contributes to the LRRK2-associated PD phenotypes (Sánchez-Danés et al, 2012; Fig 1F).

The last of these results in subpopulations of slightly misplaced neurons and alterations in mature neuronal morphology, such as changes in process branching (Kamiya et al., 2005; Duan et al., 2007; Faulkner et al., 2008; Shen et al., 2008; Enomoto et al., 2009; Kim et al., 2009; Kang et al., 2011; Kvajo et al., 2011).

These neurons show alterations in the ultrastructure of their synaptic mitochondria in PD, suggesting mitochondrial alterations might occur within these neurons (Baloyannis et al., 2006).

We found that transgenic C57Bl/6 mice that are engineered to express higher levels of self-Db on their CNS neurons have alterations in their hippocampal morphology and retinogeniculate projections, as well as impaired neurorepair responses.

In fact, regarding the possible structural correlates, the brains of heterozygous mice are decreased in size of specific regions [19], and cortical neurons present alterations in their cytoarchitecture [22] that may lead to impairment of information processing in the cerebral cortex.

At higher magnification, these neurons displayed alterations of their dendritic tree.

Interestingly, mice ectopically expressing PV in neurons show alterations in Ca2+ homeostasis and a reduced mitochondrial volume (40).

Strong nuclear reactivity was seen mainly in neurons with alterations of acute hypoxic injury such as condensed and hyperchromatic nuclei and eosinophilic cytoplasm (Figs.  4d, 5).