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We investigated neural regulation of emotional arousal.
Despite those important progresses, our understanding of neural regulation of the WAT metabolism still remains incomplete.
Brain circuits, together with their distinct neuronal populations, underlying such neural regulation have been subject to extensive research.
The participation of sensory neural regulation in bone metabolism has been widely studied.
The results implicate the involvement of 5-HT in neural regulation of response inhibition and re-engagement.
However, the physiological role of sensory neural regulation in the functional adaptation to weight bearing is not clear.
Our findings have therefore implicated an additional layer of neural regulation in the WAT metabolism, which involves the crosstalk between the neural-metabolic systems.
The complex and extraordinarily dense innervation of HCN4-positive cardiomyocytes in mouse sinoatrial node underpins the importance of neural regulation for the cardiac conduction system.
To our knowledge, this research work represents among the first examples demonstrating the physiological relevance, together with the molecular mechanism, of local sympathetic plasticity in neural regulation of the peripheral metabolism.
It has now been broadly accepted that malfunction of the neural regulation of metabolism could lead to obesity, type 2 diabetes and other profound metabolic disorders (Friedman and Halaas, 1998; Gautron et al., 2015; Myers and Olson, 2012).
Impaired Tcf7l2-mediated neural regulation may contribute to the risk and/or underlying pathophysiology of type 2 diabetes that has found high expression in genomic studies of Tcf7l2 variants.
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