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SOX1 is one of the known earliest neural precursor markers and plays essential roles in neural determination.
SOX1 plays roles in neural determination and differentiation [ 40] and is a neural stem cell marker [ 41].
Neurons could also be derived from glial cells, which are embryologically more similar, by expression of only Neurog2, a transcription factor important in neural determination [ 39].
Id1/3 in turn inhibit the actions of proneural transcription factors, such as Ascl1 and Olig2 (Benezra et al., 1990; Samanta and Kessler, 2004; Vinals et al., 2004), preventing them from expressing neural determination factors, including Otx2, and thus stabilizing the glial fate (Fig. 7E,F).
An increasing body of evidence in model organisms and human cells suggests that miRNAs have an important role in neural determination, differentiation and cell fate specification (Delaloy et al., 2010; Du et al., 2013; Fineberg et al., 2009; Makeyev et al., 2007; Smrt et al., 2010; Stappert et al., 2013).
We also included in our analysis the previously identified atonal ortholog (Pdu-ATH; not found in the EST collection) [ 35, 37] in order to study Platynereis representatives for all the main families of bHLH genes involved in neural determination and specification in vertebrates and Drosophila [ 2, 4].
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A novel dynamic structure-based neural network determination approach using orthogonal genetic algorithm with quantization is proposed in this paper.
The role of bFGF in neural fate determination could be explained by the expression of some Hox genes which are involved in spinal cord differentiation.
If this were the case, ethanol would further enhance the intermale courtship activity of fruitless (fru) males defective in FruM, a neural sex determination factor.
Eliminating the expression of the male form of the neural sex determination factor, Fruitless (FruM), in three OA suboesophageal ganglia (SOG) neurons also leads to increased male-male courtship behavior in these same contexts.
We predict that regional induction is similarly necessary for neural fate determination in A8.15/ A8.15/
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