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This work is the first large-scale study attempting to identify the genetic networks regulated by RUNX1, a master regulator in the development of the hematopoietic system and leukemia.
Despite the small number of regulatory networks identified, such as the gene networks regulated by iscR and fhlA, most gene regulation patterns maintained identical directional changes among all strains (Fig. 2b, right).
This network includes some players in the networks of AKT, MAP kinase, and cell cycle regulation, which was identified as the top functional networks regulated by EGCG.
Here we show that the same framework can be extended to describe transcriptional networks regulated by a morphogen, thereby allowing the function and architecture of cis-regulated elements and the dynamics of a gene regulatory network to be explored simultaneously.
Transcriptional networks, regulated by extracellular signals, control cell fate decisions and determine the size and composition of developing tissues.
We are currently using this system to (1) identify the neuronal targets of orphan snoRNAs, (2) delineate the neuronal networks regulated by imprinted miRNAs, and (3) determine the mechanisms by which imprinted long non-coding RNAs repress genes in cis.
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Notably, the sub-networks regulated by TNFAIP3, TRAFD1 and PML are involved in innate immune response, suggesting that these MRs may correlate with the innate immune module identified by Breen et al. These findings were replicated in an independent dataset generated on expression microarrays.
Transcriptional profiling of SOX2 GFP-expressing CSOX2 GFP-expressingpithelial CSCss upon Sox2 deletion uncovered andene netwofk regulatumour SOX2 in primary tumour cepithelialvo.
We recently used an RNA-seq approach coupled with bioinformatics analysis to identify the extensive splicing network regulated by SRSF10 in chicken cells.
We previously reported novel technology to differentiate induced pluripotent stem cells (IPSCs) into glucose-sensitive insulin-secreting beta-like cells by engineering a synthetic lineage-control network regulated by the licensed food additive vanillic acid.
Furthermore, the abundance of genes quantified by high throughput profiling has led to the discovery of a complex molecular network regulated by ER[9].
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