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Closer inspection of the most significant CNVR contributing to the CALM1 network significance (Supplementary Table 3) revealed that no single gene was significant on its own; instead, with the exception of only one gene (PTH2R), each contributing CNVR tagged highly penetrant rare defects unique to cases.
However, in contrast to ADHD where defects within the mGluR receptors themselves (GRMs) were among the most significant copy-number defects contributing to the overall network significance, we found that in the ASDs defects of component GRMs contributed only modestly to the overall significance of the mGluR pathway.
Earlier bogus "new conditions" that were deemed to undermine the orthodox case for liberal trade included the growth of cross-border capital flows, the recognition that some industries exposed to foreign competition may have strategic or network significance for the wider economy, and concerns over exploitation of workers in developing countries.
This step used a statistical procedure shown to provide optimal network significance (Lage et al. 2010).
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In order to decide which edges are significant to be included in the resulting GGM network, statistical significance was further assigned to the edges in the GGM network by fitting a mixture model (as shown below) to the observed partial correlation coefficients [ 33].
We are all born into a network of significance, children of particular people with particular stories.
GO biological function and KEGG database were used for analysis with following parameters (GO-term fusion was used and terms with less than 4 genes or less than 1% of composing genes were ignored; Kappa (connectivity) score, 0.45; Network style, "significance").
Roberts acknowledges the network's significance but remains bullish about the outcome.
We assessed network score significance with two tests.
Overlap was evaluated by considering that a fixed number of edges was independently sampled in each network and significance evaluated using Fisher's exact test.
Here we highlight oxaliplatin signaling networks, their significance and the clinical implications of these interactions that verifies the importance of network modeling in rational drug design.
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