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Pushing the network "resolution" higher by increasing the number of nodes and reducing the surface area of the ROIs would increase the quantification noise (limiting the number of fibers per ROI), which ultimately would destroy the information contained in the network model.
We were also able to detect many more modules at the same cutoff levels, suggesting greater network resolution.
Consequently, the MaxMod sub-optimality effect of limiting the coverage for the network resolution spectrum requires investigation when all module sizes may in principle count.
Our network analysis would suggest Centg3 and Elavl4 are important candidates for perturbation and subsequent global gene expression analysis for further network resolution, as they are both highly connected nodes and little is known about their function in the developing telencephalon.
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In our study we find many functionally homogeneous communities at multiple network resolutions.
As the small distances in the baseline predictions make it difficult or even impossible in many cases to identify a substructure in the networks, resolution of the subcomponent structure is significantly improved by the MST and extended MST approaches.
The resulting network allows for network-resolution adjustment based on available data and provides a starting point for further, more detailed, network reengineering with less computational complexity.
Values of λ > 1 probe the network at resolutions above the resolution limit.
In an indirect reference to Osama bin Laden and his Qaeda terrorist network, the resolution said "foreigners," meaning the Arab militants who predominate in Al Qaeda, should no longer "exploit the hospitality of Afghans and should leave the country".
The causal model applied for network conflict resolution and flight routing allocation is analyzed to demonstrate how the emergent dynamics (i.e., domino effects) of local trajectory amendments can be efficiently explored to identify conflict-free Pareto-efficient network scenarios.
These new data provide pathophysiological relevance to this novel network of resolution, formed by AnxA1/FPR2 and IL-10, and operative in NASH livers to limit and delay disease progression.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com