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Mainstream algorithms for deciding network consistency are based on searching for network refinements whose consistency is known to be tractable, either directly or by using a SAT solver.
As a result, a draft model was developed and used as a start point for subsequent network refinements.
To represent the crowd community, the top 20 active performers who created the most pieces of evidence and submitted at least 20 votes during the NVC were invited to an in-person jamboree to discuss network refinements as a group.
This prediction about TP73 is of great importance since it will result in a new prediction about IGF2 and its mRNA and will finally allow us to propose network refinements.
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During postnatal brain development, the brain's wiring pattern is further sculpted and modulated to become the full facsimile of the adult human brain, with functional brain network refinement being more rigorous than structural brain network maturation.
Intuitively one may deduce that such a global event nonspecifically collapses or erases memory traces in a network, because memory is thought to be stored on a synapse-specific network refinement [1].
After network refinement, c-MYC and ER-α were also predicted as targets from the model (Table 1 and 2).
An overlap p-value < E-04 was also applied when carrying out mechanistic network refinement within IPA.
In summary, the extended NetGenerator takes advantage of multi-stimuli multi-experiment data by network refinement and extension.
Via the graphical user interface, the user can create and edit a metabolic model by using a simple drag-and-drop mechanism for network creation and a text menu for network refinement.
If a gene had the same regulator(s) predicted from both sets, the regulatory association between the gene and regulator(s) was deemed true and cataloged for the purpose of network refinement.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com