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The best candidate pathways are then engineered within a metabolic network of microorganisms that serve as synthetic platforms for synthetic biology.
The metabolic network of microorganisms is very well understood: it can be considered as a graph having enzymatic reactions as edges and metabolites as nodes.
Hopefully, metagenomic approaches will not only yield more insight into the role of the microbiota in health and disease, but may also elucidate the complex network of microorganisms being part of the gastrointestinal tract.
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Adhesion of bacteria to a substratum constitutes the initial step for colonization and development of complex networks of microorganisms on surfaces [1, 2].
By contrast, the underlying metabolic networks of microorganisms are under strict control and relatively rigid, which poses a significant challenge for rational metabolic engineering approaches.
Reports from the recent literature, discussed in this Synthetic Biology Select, include the rational design of a functional enzyme, an approach for creating more stable proteins, and systems-level analyses that reveal unexpected sophistication in the regulatory networks of microorganisms.
For example, needle-leaved Canadian evergreens make the most of scant sunlight and their leaf litter feeds the acidic soils that nurture networks of microorganisms, such as nitrogen-fixing bacteria, which in turn, enriches the food for the trees.
Environmental changes trigger a cascade of cellular events, and regulatory networks of microorganisms serve to prime cells to be prepared for later challenges even before they arise [1], [2].
Because microbial ecosystems form interacting networks of microorganisms, the presence (or abundance) of 1 type of bacteria will most likely affect the presence of others.
It is well known that the metabolic networks of microorganisms are very complicated and respond in a complex manner to environmental conditions.
While we expect that it will take some time for this vision to become reality, already now CoryneRegNet is a free open-source central repository and analysis tool for regulatory networks of microorganisms that is easy to extend because of its ontology-based design.
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CEO of Professional Science Editing for Scientists @ prosciediting.com