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For example, in the protein-protein interaction network, interacting binding sites usually show co-evolution [18], [21], [23], [25].
Another relevant hub is SMAD4, which seems to have an important place in the network, interacting both with intracellularly expressed genes like RRAS2 and PARD3, as well as an extracellular matrix gene, fibulin-1 (FBLN1).
FG7142 has been shown to induce anxiety-related behavioral and physiological responses in a variety of experimental paradigms across numerous mammalian species including humans [ 1- 5] and to activate an anxiety-related neural network interacting [ 13, 14] with other systems of neurotransmitters such as monoamines [ 6- 9] and excitatory amino acid [ 10].
When all genes are included in the network that cause both increases or decreases in Mn genes encoding the Mn transporters Smf1 and Smf2 appear in the network interacting with PMR1, and also bring in SMF3 via a genetic interaction with SMF1.
BAF is an essential component of the nuclear lamina network, interacting with both A- and B-type lamins as well as nuclear membrane proteins and chromatin [13].
Genes encoding network hubs and superhubs tend to be more weakly co-expressed with the genes coding for their network interacting partners (IPi) than those genes represented by network peripherals-A and –B.
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This network interacts with part of the t1A nucleotide and helps to lock Argonaute2 onto its microRNA target sites.
Recent models have highlighted the important multivariate characteristics of the ErbB-signaling network in proliferation as the ErbB signal transduction network interacts with a variety of other signaling pathways.
Assuming that the probability P(k) that a molecule in a network interacts with k other molecules follows a power law [ P(k) ~ k -γ ], a high γ value indicates that there were few highly connected nodes in the network.
However, because these phenomena often consist of human networks interacting with engineered networks, analyzing the properties of the multi-layer network systems may provide more accurate insights.
This source pattern conformed very strongly to our expectations regarding functional processing networks interacting in the post-naming interval (see Introduction).
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