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Finally, we examine intermediary infrastructures designed to extend the support of the core network for the development and deployment of new services.
High expression of Clara cell-associated secretoglobin genes in the SAE was accompanied with enrichment of transcription factors forkhead box A1 (FOXA1), NK2 homeobox 1 (NKX2-1), FOXA2, and CCAAT/enhancer binding protein, alpha (C/EBPα), transcription factors that constitute a major regulatory network for the development and maintenance of SAE and Clara cell differentiation [ 43, 63- 65].
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We will analyse management in these networks in light of the experience of various European institutions that actively participate in networks for the development of technological projects.
Hypothesis 2a: Firms involved in triple-helix networks for the development of innovations will be more innovative than those which source innovations in the market or rely on internal and vertically integrated hierarchies.
As we start constructing gene networks for the development of morphological features (such as arthropod - or even other bilaterian - segments [ 5], bilaterian nervous systems [ 6] and now notochords [ 4]), the need and the ability to distinguish between homologous, convergent or superficially similar molecular networks are becoming more apparent and more feasible.
Dysregulation of the ubiquitination network accounts for the development of numerous diseases, including cancer.
However, in many of the examples above, it is still unclear how the gene regulatory network, responsible for the development of each serial homolog, became deployed at each body location and gained individuation from the other units to generate body plan diversity.
Taking the correlation coefficient as control strength for NCA, we define a matrix of regulatory relationships between the selected TFs and their target genes, and generate a regulatory network for the pollen development.
Comparatively, little is known about the mechanisms and gene networks responsible for the development of primitive macrophages and neutrophils.
The emergence of sensor networks calls for the development of distributed algorithms for a number of tasks to replace the traditional centralized methods.
In summary, the protein variations identified in this study, indicate that numerous cellular pathways are activated leading to interaction of multiple proteins during vaginal and cervical tumourigenesis, which underscore the complexity of the cellular signalling networks responsible for the development and progression of cancer.
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