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Network flux.
The network efficiency and network flux are both measures of the connectivity of the pathway network.
Network efficiency (NE) and network flux (NF) are both global measures of the network connectivity.
Network efficiency and network flux were both measures of the network connectivity [5, 18, 26].
The geometric mean of the degree of decrease of network efficiency and the degree of decrease of network flux.
By integrating molecular docking and network analysis, network efficiency, network flux and their combination can quantitatively describe the inhibitory effects of compounds.
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The dFBA model can be developed by linking intracellular metabolic network fluxes with the changes in extracellular fluxes (e.g. sugar uptake and inhibitor conversion rates).
Human and food mobility network fluxes are estimated using the radiation model of (Simini et al. 2012) (Additional file 1) that is based on the population distribution.
Recently, a highly uneven distribution of metabolic network fluxes has been described in Escherichia coli that defines a high-flux backbone containing the most important (and most familiar) metabolic reactions.
It is further demonstrated that the optimal strategy for the effective increase of network fluxes is through the coordinated amplification of a small number of steps in order to maintain maximum throughput while ensuring an uninterrupted supply of intermediate metabolites.
This method extends the concepts of Metabolic Control Analysis to groups of reactions and offers the means for calculating group control coefficients as measures of the control exercised by groups of reactions on the overall network fluxes and intracellular metabolite pools.
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