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[Redrawn from [35]] Fig. 19 Network burst distribution in number of spikes, together with geometric (red) and power law (blue) fit; Δt, the mean inter-spike interval, is the time bin used to calculate the distribution, and β is the slope exponent of the fit.
Fig. 18 Network burst distribution in number of spikes, together with geometric (red) and power law (blue) fit; Δt, the mean inter-spike interval, is the time bin used to calculate the distribution, and (beta=-1.62) is the slope exponent of the fit.
Obviously, the impact of a single stimulus pulse is much larger if it triggers a network burst.
We stimulated all electrodes in random order, at various amplitudes to select a stimulation electrode and amplitude that frequently induced a network burst.
Network burst activity of spontaneous polysynaptic AMPA-R mediated events was recorded at −80 mV in BicPic without TTX in separate slices.
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During the second stage neurons show correlated firing, which is initially mediated by electrical synapses and subsequently transforms into network bursts depending on chemical synapses.
Namely, the rate and width of the network bursts were found to increase with cluster size.
We selected a stimulation electrode that induced network bursts upon most initial test stimuli.
However, the single neuron firing is not sufficient to generate collective network bursts.
Such aborted network bursts were previously reported in uniform cultures [19].
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