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Kinetoplastid parasites, such as Trypanosoma or Leishmania are very polarised cells that contain a dense and complex membrane network around the flagellar pocket, an invagination of the plasma membrane where the flagellum emerges from the cell body and where most of the exchanges with the external milieu occur [ 12].
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The other seven proteins are able to reach essentially the whole A. thaliana network (around 93%).
In L. major, META1 is reported to localize around the flagellar pocket [ 16], the site for exo- and endocytosis in Leishmania [ 36].
Given the highly polarised organisation of the trafficking in kinetoplastids around the flagellar pocket, this would be consistent with a role of LmjF28.1470 in the cellular exchanges with the external milieu.
(3) NIMS only makes use of a small fraction of the network around the network targets.
The discovered biomarker is composed of the network around the PDGF pathway.
21 We assembled small regulatory networks around the significantly differentially expressed miRNAs where possible.
The separation of flagellar genes in different modules is strongly supported by the LeMoNe clustering), suggesting the presence of condition-specific regulation in the flagellar gene network, and corresponds to the difference in regulatory input between different classes of flagellar genes.
A mitochondria-associated cysteine-rich protein (∼17% cysteine) forms a disulfide-hardened capsule around sperm mitochondria at the flagellar midpiece [4].
We performed stochastic simulations of the chemotaxis network and resulting flagellar motor activity and then applied the veto rule that CW rotation of a single flagellum leads to cell tumbling.
The chemotactic signaling pathway is a network of chemical reactions propagating signals from the receptors to the flagellar motors.
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