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Net influx rate.
Net influx rate (Ki) and global mean CMRglc are reported.
In addition, Patlak analysis, a kinetic linearized model [16] for irreversible tracer uptake, was applied to the interval 10 to 60 min post injection to generate an image of net influx rate [K i] of FDG, which is proportional to the metabolic rate of glucose.
First, using NLR, TACs were fitted to the standard irreversible two-tissue compartment model, providing the three rate constants K 1, k 2, and k 3 as well as the blood volume fraction V B. Second, the validity of the Patlak linearization [28] was investigated by comparing regional values of the net influx rate constant K i with those obtained using NLR.
K i (K1 k3/(k2+ k3)) is the net influx rate constant for FDG.
Also Patlak-based net influx rate constants (Ki) of the lesions decrease markedly in the glucose loaded state (mean −25%, p < 0.05), while MRglc is on average 36% higher.
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So, even though the AIC analyses suggested a model which did not constrain k 4 to be zero, the net influx rates were still well correlated with those of Patlak analyses.
The resulting kinetic rate constants K1 (transport across the blood brain barrier) and Ki (metabolic rate constant or net influx constant) were compared with those obtained from the same data using the input function derived from blood samples.
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Among these KMAs, Patlak's analysis is usually considered as a gold standard that provides the 18F-FDG net influx constant (i.e., the uptake rate constant, Ki) from a linear fitting of graphical data [7].
Prolonged transients occur because calcium accumulates at the onset of the transient before the net indicator binding rate can approach the influx rate.
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