Our results clearly suggested that PP2A inhibition impaired net glycogen synthesis through impairment of GS activity and glycogen synthesis as well as stimulation of phosphorylase activity and glycogen breakdown.
These findings all point toward deficiencies in ACh innervation, ACh synaptic activity, or ACh receptor expression, producing a net outcome of impairment of ACh synaptic function.
In mice, aging has recently been shown to result in a significant impairment in NET generation both in vitro and in vivo, the latter being associated with marked bacteraemia in a model of Staphylococcus aureus infection (Tseng et al., 2012).
Thus, an age-related impairment in NET formation may impact negatively upon not only the ability of neutrophils from older adults to confine invading pathogens to the initial site of infection but also their capacity to influence the early phases of an adaptive immune response.
A more recent study identified a subset of patients with lupus nephritis whose sera were impaired in degrading NETs, suggesting that such impairment could be pathogenic [ 4].
The hypocalcemia observed in lead-exposed H. fossilis may be attributed to the impairment of either net electrolyte influx at the gill or renal function.
After short-term deltamethrin exposure, adult Heteropneustes fossilis (freshwater catfish) showed hypocalcemia and the researchers attribute this condition to the possible impairment of either net electrolyte influx at the gill or impairment of renal function (Srivastava et al. 1997).
Excluding the $961.6 million noncash net security gains and $1.1 billion impairment charge losses, Ambac posted a per-share loss of $1.53, wider than the 65 cents analysts polled by Thomson Financial were expecting.
have very recently shown that heart failure in Atgl−/− mice is not caused by lipid accumulation per se but is a net result of a severe impairment of cardiac mitochondrial function [14].
In the other half of subjects (termed DAT-i inflexible, with a "stuck" profile), a more marked impairment emerged: a net preference for LL seemed to be expressed, which was likely the result of a rigid pattern of choice.
