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Similarly, nest formation and lack of dendrites argue against typical melanocyte behaviour.
Preliminary termination of either new oocyte or granulosa cell nest formation results in premature ovarian failure [ 85].
Firstly, these markers were more likely to be positive in the samples displaying nest formation (group 1) than in those with diffuse infiltration only (group 2; Table 2, Fig. 2).
This experimental paradigm is based on a reduction of the nesting material (2/3) and the introduction of a fine gauge steel grid to house the dam and pups in order to prevent stable nest formation.
Besides physaliferous cells and the nest formation of chordoid tumour cells, in chordomas and not in cartilaginous tumours, immunohistochemical labelling is an important tool for differentiating these two tumour types and to confirm the diagnosis [ 28].
The distribution of galectin has been associated with stage III-V with cellular changes such as dysplasia, cancer cells' nest formation, breakage of the basement membrane, and infiltration of cells into non-native tissue.
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Breakdown of germ-cell nests and formation of primordial follicles are key early events in mammalian folliculogenesis.
Our results clearly show that Notch2 function in somatic granulosa cells is required for breakdown of germ-cell nests and formation of primordial follicles.
In wild-type mice, breakdown of germ-cell nests and formation of primordial follicles are normally complete within a few days of birth.
Our work demonstrates that Notch2-mediated signaling in the somatic-cell lineage of the mouse ovary regulates oocyte apoptosis non-cell autonomously, and is essential for regulating breakdown of germ-cell nests and formation of primordial follicles.
We have shown that Notch2-mediated signaling in the somatic-cell lineage of the mouse ovary is essential for regulating breakdown of germ-cell nests and formation of primordial follicles.
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