Communication of sensory nerves responsive to noxious stimuli (chemical, mechanical, or inflammatory) with the central nervous system occurs via vagal, pelvic, and splanchnic nerve pathways [11, 12].
More comprehensive sampling and deeper sequencing is needed to detail early nerve-dependent transcriptional responses because several genes that are known to be nerve-responsive during the wound-healing phase were not identified in this study (for example sp9, [ 11]; prrx1, tbx5, [ 10]).
These observations suggest that lack of ACh-evoked activity promotes increased AChR clustering beyond the "central nerve-responsive zone" of WT mice.
Furthermore, significant expression of neuroligin 1 in the wings and legs (Table 4) suggests a putative role in nerve endings responsive to sensory input.
Isolated pulmonary vagal afferent nerves are responsive to TRPV1 stimulation.
(2) Isolated pulmonary vagal afferent nerves are responsive to TRPV1 stimulation and (3) TRPV1 agonists, such as capsaicin, elicit cough in animals and man [ 18- 21].
Akash Kapur's essay hit a responsive nerve.
Animal models of chronic pain conditions resulting from peripheral inflammatory reactions or nerve injuries are responsive to treatment with cannabinoid agonists.
Both of these vagal afferent nerve subtypes are responsive to acid but largely insensitive to changes in airway luminal pressure, stretch or airway smooth muscle contraction.
Currently, two modalities of neural stimulation are in widespread use for treatment of epilepsy: vagus nerve stimulation and responsive neural stimulation.
This is supported by Aoki and colleagues, who have identified NGF-responsive nerve fibres as the predominant neuronal subtype innervating the peripheral regions of the healthy annulus fibrosus [ 11].
