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These findings support a general model for IC pelvic pain due to mast cell-sensory nerve interactions, and similar interactions may drive pelvic pain in IBS.
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Fig. 2 Mast cell-nerve interactions in the human gut.
Testing this in an intact system has been difficult because the complexity in skin-nerve interactions prohibits isolation of the skin and neuronal output (a behavioral reflex or the pattern of axonal firing) since any natural stimulation (e.g., mechanical or thermal) simultaneously affects both keratinocytes and sensory neurons.
The gating of channels with a capacity for ion transport is the basis of the many nerve-nerve, nerve-muscle, and nerve-gland interactions underlying neurobiological behaviour.
We then monitored NMJ to determine whether autophagy inhibition in old mice was sufficient to destabilize muscle-nerve interaction.
The most striking conclusion is that autophagy controls two important destabilizing factors that are (1) the removal of dysfunctional mitochondria that produce ROS and (2) the endosome recycling of AChR that affects MuSK localization and muscle-nerve interaction.
Estrogen increases blood flow, removes cell-damaging compounds called free radicals and increases the dendritic spines needed for nerve cell interactions.
For both species the most represented categories within the EO up-regulated genes are related to ion channel transport (e.g., sodium ion transport), multicellular organismal development, development and patterning of nerves (branching morphogenesis of a nerve; semaphorin interactions; axon guidance).
High glucose caused the demyelinization and axonal degeneration of nerves, which facilitate cancer cell invasion into nerves and enhanced interactions between nerve and cancer cells by increasing the expression of cytokines such as GDNF.
In addition to their association with nerves, an interaction of hADSC with blood vessels was also noted (Fig. 4C′).
Nerve growth factor TrkA interactions could thus be a new therapeutic target.
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