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Acetylcholinesterase is a very rapid enzyme, essential in the process of nerve impulse transmission at cholinergic synapses.
Of the genes with increased expression at P13 versus P5, many are involved in nerve impulse transmission.
Several of these genes (such as Syt5, Syt9 and Syt11 encoding synaptotagmins; and a few CACNA genes encoding voltage gated calcium channels) act in nerve impulse transmission.
For genes with increased expression at P13, those that are involved in nerve impulse transmission, metal ion transport, secretory pathways and glycolysis are enriched.
This leads to a build up of excess acetylcholine, a neurotransmitter essential to normal nerve impulse transmission.
The principal role of cholinesterase (ChE) is the termination of nerve impulse transmission at the cholinergic synapses by rapid hydrolysis of acetylcholine (ACh).
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21 Zinc also plays a role in cell signaling and has been found to influence nerve-impulse transmission.
This argument relies on assumptions about the capacity of such animals to feel pain, the thermal thresholds for tissue freezing, the temperature-dependence of nerve-impulse transmission and brain activity, and the magnitude of thermal differentials within the bodies of rapidly-cooling animals.
Benzodiazepines work by enhancing the action of the neurotransmitter gamma-aminobutyric acid (GABA), which inhibits anxiety by reducing certain nerve-impulse transmissions within the brain.
We found two gene groups being enriched for the target genes of the TFs with poor correlation of activity versus gene expression (transmission of nerve impulse, synaptic transmission, P = 8.64 E-03, Supplementary Table S2).
For example, cell cycle, DNA replication and p53 pathway (KEGG) are perturbed only in cancer, while transmission of nerve impulse, synaptic transmission, nervous system development, long term potentiation, long term depression, axon guidance and gap junction are perturbed only in neurologic diseases.
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