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This assessment screens for nerve injuries characterised by changes in afferent or efferent nerve function such as changes in nerve conduction [ 2].
Generally, parameters for nerve function, such as nerve conduction velocity and vibration perception threshold (VPT) are used as primary variables of efficacy of ARIs [ 5– 9].
Patients with other types of nerve injuries as well as known diseases that could influence nerve function, such as diabetes, alcohol abuse, or neurological disorders, were not included in the study.
Clinical tests to assess peripheral nerve disorders can be classified into two categories: tests for afferent/efferent nerve function such as nerve conduction (bedside neurological examination) and tests for increased mechanosensitivity (e.g. upper limb neurodynamic tests (ULNTs) and nerve palpation).
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In this study, CHEP has the highest correlation with the IENF density compared with other parameters of sensory nerve functions such as thermal thresholds in quantitative sensory testing.
While diabetic neuropathy is observed in STZ-treated diabetic model, taurine supplementation improved the defective nerve functions, such as nerve conductance deficits and hyperalgesia, and ameliorated the deficit of nerve blood flow (Li et al. 2005b; Obrosova et al. 2001a, b; Pop-Busui et al. 2001; Stevens et al. 1993).
Third, no objective peripheral nerve function tests, such as nerve conduction studies, were used that could have been more sensitive to a treatment effect with actovegin than VPT as a psychophysical measure.
While rigorous studies of peripheral nerve function in such mice have not been reported, rotarod tests at 3 months of age did not reveal impairments (Okamoto et al., 2013).
Third, prospective assessment of neuropathy included nerve function rather than nerve structure, such as skin biopsy or corneal confocal microscopy, 30 since the latter became available only recently.
Trace amounts of metals in biologic systems are essential for processes such as respiration, nerve function, and cell metabolism.
Neurological examinations will be conducted, and information regarding the importance of the findings will be given (e.g. positive comments about normal findings such as normal nerve function in legs).
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