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The formed ELPs were assessed as an ideal nerve conduit for peripheral nerve regeneration.
Therefore, we proposed a two-stage process for wound healing or nerve conduit preparation.
Nerve cable with myelinated axons was found in the crosslinked PCLF2000 nerve conduit.
The nerve conduit alone was implanted in the control group (n = 10).
The axonal continuity recovered through the nerve conduit at 8 weeks after surgery.
In addition, the accuracy of the numerical model was well validated by good agreement of experimental and numerical results of nerve conduit compression tests.
In this context, we designed a nerve conduit (NC) with adjustable release kinetics of nerve growth factor (NGF).
This study stimulates further work on the potential use of this synthetic biodegradable PCL nerve conduit in a clinical setting.
This confers patient morbidity and increases surgical time therefore innovative experimental strategies towards engineering a synthetic nerve conduit are welcome.
The inclusion of nerve conduit lumen fillers has also been demonstrated as essential to enable nerve regeneration across large defect gaps.
The target reinnervation and functional recovery induced by the regenerative nerve conduit suggest that SAPNS-based conduit is highly promising application in the treatment of peripheral nerve defect.
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