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Vainio also suggested that metatarsalgia associated with rheumatoid arthritis should preferably be called Morton's metatarsalgia, as the nerve changes in this group of patients are not typical of neuroma.
This study aimed to analyze bilateral corneal nerve changes in patients with HZO by in vivo confocal microscopy (IVCM) and their correlation with corneal sensation as a measure of nerve function.
To examine phenotype progression over time, we tracked alterations in the plantaris nerve, as this distal nerve is a sensitive indicator of nerve changes in mouse models of hereditary motor and sensory neuropathies (Frei et al., 1999; our unpublished observations).
These findings may be due to the pressure-independent mechanisms involved in the pathogenesis of optic nerve changes in glaucoma or they may indicate that corneal hysteresis is somehow associated with the accumulation of IOP-related optic nerve damage.
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These optic nerve changes were reported in patients who experienced scintillation scotoma and photopsias mainly during paclitaxel infusion [ 18- 20].
The FRMD7 knockout mouse model would be suitable model for further investigating the optic nerve changes and nerve fiber layer changes described in this study.
Furthermore, the increased m-ratio in Gdap1−/− nerves reflects changes in mitochondrial sizes and is not indicative of a major transport deficit.
Pathological changes were characterized by massive infiltration of macrophages and CD8+ T cells, demyelination and axonal damage in peripheral nerves, while changes in spinal cords could be secondary to the PNS damage.
This reflex response, which is largely mediated by sympathetic nerves, involves changes in blood flow, increased skin turgor, hyperalgesia in localized areas of skin, dysregulation of the organ at the corresponding metameric level, as well as increased muscle tone [ 18– 20].
In summary, proximity of the laser beam to the nerve gave transient changes in electrophysiological nerve function measures, while the bipolar forceps gave an all or nothing nerve ablation and damage from the laser beam placed above the nerve was dependent on beam energy.
It is observed that retinal nerve structures change in rats treated with six intravitreal injections of ranibizumab at weekly intervals.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com