(2) Validating the time-variance: the rate of change of the ECM shows how strongly the parametric channel changes between two neighbouring time instants.
The peaks are chosen such that at time, the cochlear response satisfies the criterion that it is larger than the neighbouring time samples, on either side of it, as follows:, and.
The negative and positive peaks, corresponding to N75 and P100 components respectively, were identified by means of an automatic procedure detecting local minima/maxima (taking into account ±2 neighbouring time points).
Pair-wise comparison (Wilcoxon test) was used to compare the difference in protein levels between two neighbouring time points.
In other words, a temporal block does not represent the coherent expression solely as a bicluster but represents the similar expression pattern change events (condition (a) in Definition 2) as the concept of gene reorganization across the neighbouring time windows [ 13].
Additional analyses were undertaken that described the health service costs incurred within the final few months of life with metastases (the terminal phase), as well as cost analyses in neighbouring time periods to identify any trends in the observed costs of treating breast cancer.
