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29% of expected CER will never be issued due to failure of projects (negative validation, project withdrawn, …), 12% were not issued on time due to delays during the approval process (validation and registration), 27% were not issued on time due to delays at issuance, and only 1% will never be issued due to underperformance of projects in terms of CER delivered per day.
The negative validation contained 250 not nucleic acid binding proteins (Shazman and Mandel-Gutfreund, 2008).
Our predictions showed accuracy of 72.9% for the mRNA-binding set and 79.2% for the negative validation.
To balance the label frequencies, we also select 39 transcripts from benign, reactive lymph node tissue as the negative validation set examples.
In addition to those positive and negative validation peaks, we also compared our results with results obtained using existing methods on the same ChIP-chip and ChIP-seq data (Cheng et al., 2009).
A possible explanation for the difference is that negative validation of the algorithm-predicted MRE has been reported for only one or a few tissues, which may significantly differ from other tissues in the EST libraries.
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We found that high expression of NEAT1 in the ER-negative validation samples correlated with poor survival.
High expression of TOPORS antisense RNA 1 (TOPORS-AS1) was associated with good outcome in the ER-positive validation samples and with poor outcome in the ER-negative validation samples.
Both negative manual validation and incorrect validation of the cleaning process by the washer-disinfector lead to withholding of the medical product from clinical use.
Bélanger et al. [ 25] found that the maintenance of PA in adolescents is associated with supportive social environments, whereas a decline is associated with negative social validation, poor social support, and barriers related to access.
Given that the efficacy and efficiency of research depends on reducing both false positive and false negative conclusions, validation approaches should be developed that can better prevent both types of erroneous conclusions.
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CEO of Professional Science Editing for Scientists @ prosciediting.com