Sentence examples for negative stats from inspiring English sources

More important, the format has more negative stats.

The beneficial effect of reducing STAT3 and STAT5 activity in cancer has been demonstrated in cell culture and animal models using overexpression of dominant negative STATs and knockdown of STAT expression with siRNAs.

To further confirm the role of two Stat-5 isotypes in tumor-induced CD4+ T cell demise, Jurkat T cells were over-expressed with wild-type Stat-5A/Stat-5B, C-terminal truncatedominantnegativeive Stat-5 Stat-5A7133 Stat-5B718B718) or constitutively active Stat-5A (Stat-5A1*6) genes (Fig. 4B) and then incubated with tumor-culture supernatants.

Control cells were also previously created by transfection with a mutated or negative STAT-3 shRNA form of the short hairpin RNA against STAT-3 (NEG 4.17 cells) and do not show significant STAT-3 knockdown [ 7].

We then examined the effect of a dominant negative STAT-3 DN (STAT3β), STAT6 DN and STAT3 mutant at serine 727 on IL-9 mediated CCL-11 promoter activity in ASM cells.

Constitutively active Stat-5A (Stat-5A1*6) over-expression efficiently elevates Bcl-2 levels in CD4+ T cells and protects them from tumor-induced death while dominant-negative Stat-5A over-expression fails to do so, indicating the importance of Stat-5A-signaling in CD4+ T cell survival.

The relevance of STAT activation to growth control is made apparent in experiments performed in cell lines or animals that lack specific STAT proteins, by the use of antisense molecules to specific STATs or by the use of dominant-negative STAT protein encoding constructs.

This apparently disagrees with experimental studies in which transfection of dominant-negative STAT-3 completely abolishes the anti-apoptotic effect of IL-6 on RCC cells [ 37], but also with an early report implicating the constitutive activation of STAT-3 in the metastatic potential of RCC cells in a small series [ 38].

The SOCS gene products are known STAT-induced negative regulators of STATs phosphorylation.

Much of the attention was negative, as Stat News and others noted.

One possible explanation comes from the observed differences in positive results between the three tests (Figure 1a), and in particular the large number of cases where badgers tested positive on IFNγ but negative on Stat-Pak (Table 2).