Suggestions(5)
Exact(26)
The mouth of the barrel contains more positive than negative residues as shown in Figure S2, and may therefore attract negatively charged ligands.
Additionally, a relatively high number of conserved positive and negative residues are found.
Arg392 is positively charged and makes a salt bridge with the negative residues Asp42 (α2) and Glu236.
Similarly, GeminiDistances misses 8 and 25 false negative residues compared to SCOWLP (55 minus 47) and to PPIDB (66 minus 41), respectively.
Hence, SCOWLP identifies 10 (55 minus 45) false positive residues and 21 (66 minus 45) false negative residues compared to PPIDB.
Deletions inside this region, which severely affected the balance between positive and negative residues, impaired self-assembly of Rod fragments in vitro and localization of MHC-IIB into the cytoskeleton in vivo.
Similar(33)
In contrast, ZnT6, 7 and 8 contains tyrosines that lack negative residue in position +3.
p.Gly162Asp is one of the most dramatic mutations we identified because it introduces a negative residue inside the hydrophobic core.
Conversely, Ala11 completely lost the ability to interact with TP5 due to the lack of negative residue in its side chain (Fig. 7B, D), which showed that Glu11 acted as a key effect on the binding between TP5 and HLA-DR.
The Asp259 stands out as a negative residue in an otherwise positive surface.
In RFH there is a universal positive Arg residue instead of the usually negative residue in RF1 and RF2.
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