Sentence examples for negative regulating from inspiring English sources

In addition, SIK is a direct transcriptional target of TGF-β signaling, and therefore it functions as a negative regulating feedback mechanism to limit TGF-β signaling [ 38].

Indeed, p53 is able to regulate cell survival by inhibiting the PI3K/AKT/mTOR survival pathway, such as by positively regulating the expression of AKT/mTOR pathway inhibitors [ 76, 78] or by negative regulating the expression of PI3KCA, encoding the p110α catalytic subunit of PI3K [ 75, 77].

In addition, it was demonstrated that this gene have a role as an intrinsic endogenous regulator of homeostasis of the innate immune system by negative regulating inflammatory signaling [ 44] and that free fatty acids can repress its activation [ 46].

COP1 might be a tumor suppressor by negative regulating ETV1 in patients with TNBCs.

The reduction in p16 promoter activity of Δ417 and activity recovery for Δ160 indicating a negative regulating DNA element may exist between −417 and −160 region.

Targeting negative regulating molecules (CTLA4, PD-1/PD-1 L, CD25) is therefore a novel therapeutic option to reverse undesired immune silencing.

The result indicates that cool-season turfgrass and forage grass may have more negative regulated genes compared with positive regulation ones in the heat stress response pathway.

Also in rice, OsEATB, which is restrained by ethylene and abscisic acid in expression level, negative regulate gibberellin biosynthesis by down-regulating a pathway gene (Qi et al. 2011).

As expected, overexpression of srGAP3 efficiently attenuated VPA-induced neuronal differentiation of TET1-depleted Neuro2a cells (Fig. 6D and 6E), indicating that TET1 negative regulate neuronal differentiation through srGAP3 expression, independent of its enzymatic activity (Fig. 6F).

Although, these observations suggest that increased levels of IFI16 protein negative regulate the expression of c-MYC in certain tumor cell lines, it remains unknown how increased levels of the IFI16 protein in human normal cells contribute to cellular senescence-associated cell growth arrest.

This site is constitutively phosphorylated by GSK and negative regulates eIF2B activity.