Exact(3)
Hospitals should avoid the need for elective transfusion of group O RhD negative red cells to non-O RhD negative recipients.
By contrast within the 28 transplants in HCV negative recipients, there were 26 patients with one transplant and one patient with two transplants.
Multivariate meta-regression showed no significant difference in CMV [cytomegalovirus] disease after allowing for potential confounding or effect-modification by prophylactic drug used, organ transplanted or recipient serostatus in CMV positive recipients and CMV negative recipients of CMV positive donors".
Similar(57)
In a multivariate regression model, factors favoring CD4+ T cell recovery ≥ 200 cells/µL were lower dose antithymocyte globulin (ATG) (hazard ratio [HR], 3.93; 95% confidence interval [CI], 2.3 to 5.83; P = .001), negative recipient cytomegalovirus (CMV) serostatus (HR, 3.76; 95% CI, 1.9 to 5.74; P = .001), and younger age (HR, 2.61; 95% CI, 1.01 to 3.47; P = .03).03
Prophylactic antiviral treatment for CMV was required in cases of a CMV positive donor graft and a CMV negative recipient.
After allotransplantation, cytomegalovirus (CMV) may be transmitted from the donor organ, giving rise to primary infection in a CMV negative recipient or reinfection in one who is CMV positive.
Such organs would not be used for HIV-negative recipients because of the risk of infection.
The poor outcome of HCV-positive recipients has resulted in divergence in the transplant outcomes between HCV-positive recipients and HCV-negative recipients.
The serum creatinine levels, measured at 1 year after transplantation, were significantly lower in the microchimerism-positive recipients than in the microchimerism-negative recipients [ 84].
It was reported that the survival time of transplanted kidneys was significantly longer in microchimerism-positive recipients (8.7 years) than in microchimerism-negative recipients (5.4 years).
However, the ex vivo treatment of HCMV-positive transplants, for instance bone marrow or HSC purified therefrom, could be readily envisioned to purge latently infected cells prior to engraftment, notably in the high-risk setting of HCMV-negative recipients.
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