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The other 52 patients (88.14%) had negative provocation test results).
In case of a negative provocation test, any DHS therapy becomes needless.
In the case of a negative provocation test, special emphasis should be put on the differential diagnosis and the cause of the pain should be carefully evaluated (endodontic or cariologic origin, orofacial pain, etc).
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Instead, there was an increase of cortisol after negative emotion provocation.
We defined idiopathic cough as a cough that lasted for more than eight weeks in the absence of any abnormality in the clinical examination, chest radiograph, CT sinuses, lung function, negative histamine provocation test, differential cell count of induced sputum and no pathological reflux during a 24 hours pH/impedance monitoring.
Concurrently, this polymorphism was confirmed in neither of the patients with negative results of provocation test.
The first variant contained change in nucleotides in 38589682 position (C>A) of reference sequence and was observed in 1 patient with negative result of pharmacological provocation.
Patients who were negative at the nasal provocation were challenged sublingually with increasing doses of aspirin to reach the cumulative doses of at least 350 mg of aspirin.
These DNA variants were observed in all the examined patients apart from one individual who was asymptomatic and had negative result of pharmacological provocation test.
BS was diagnosed in 2 of the persons while the other 2 individuals were family members of patients with negative results of pharmacological provocation.
Clinically, there were 2 asymptomatic individuals related to each other (father and son); one had negative result of pharmacological provocation (father) whereas the second patient had type 1 change in ST segment typical of BS.
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