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The false negative rate is the number of false negative procedures divided by the sum of the true positive and false negative procedures (1-sensitivity), although some investigators calculate it in their own way.
Not only are there different reference tests, which are determined by the results of the FNB procedure, namely histopathology after surgical resection for all positive FNB tests and clinical follow-up for most negative procedures, but verification is also partial.
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These obscure orders give effect to ministerial decisions and simply come into force within 40 days unless revoked (in either House) by "negative procedure" – an almost unheard of occurrence.
11 Finally, the morbidity associated with completion dissection is significantly greater than that of SLND for melanoma, so that the clinical cost of a negative procedure is greater than with SLND alone.
Also, many investigators calculated the rate of false-negative procedures over the entire group of patients or over the group of sentinel node negative patients.
By impressing the texture of patterned cloth onto thin Japanese paper and adding to and subtracting from the result, James Nelson uses positive and negative rubbing procedures.
Selection of gene deletion mutants by positive and negative selection procedures were performed as described[9].
Exosomes obtained from the ultracentrifuge pellets were examined by EM or stained using negative staining procedures with uranyl acetate.
Negative control procedures included identical steps, but without primary antibody.
In addition, the method could be particularly valuable in cases of extensive metastatic involvement, which is the cause of false negative SLNB procedures (Dequanter et al, 2001).
Negative control procedures were performed to assess the specificity of the ISH signal: 1) omitting Dig-labeled probe; 2) omitting anti-Dig antibody; 3) omitting Dig-labeled probe and anti-Dig antibody.
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