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However, all these genes were repressed in the Oct4 negative outgrowth cells that had lost pluripotency.
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They were scored as negative for outgrowth if no epithelial structures could be observed.
Interestingly, the responsive tumors showed focal outgrowths negative for CRBP1 staining, which may correspond to nonresponsive precursors (white arrows in Figure 7C).
Previous in vitro studies have shown apoE4 to have a negative effect on neuronal outgrowth when incubated with lipids.
In contrast, RhoA is a negative regulator of dendrite outgrowth in various organisms and cell types [47], [48].
OsTB1 encodes a putative transcription factor carrying a basic helix-loop-helix type of DNA-binding motif (named the TCP domain) and functions as a negative regulator of the outgrowth of tillering buds [35].
The second one is O sTB1 which acts as a negative regulator controlling tiller outgrowth in rice [ 14].
Moreover, ectopic sFRP1 expression in MDA-MB-231 cells has a strong negative impact on tumor outgrowth and blocked lung metastases.
An up-regulated putative carotenoid cleavage dioxygenase (CCD1, TIGR LOC_Os12g44310) is a member of a gene family believed to be involved in ABA synthesis in Arabidopsis and which in rice are associated with the negative regulation of the outgrowth of axillary buds [ 47].
However, this mutant had a strong dominant-negative effect on neurite outgrowth.
C271Y had the most dramatic effects, resulting in poor protein expression, aberrant localization to the nucleus and dominant-negative inhibition of neurite outgrowth.
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