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1000 random negative molecules are added to the original training sets.
Second, we show similar performance using a simulated target-prediction experiment where negative molecules are used during the assessment.
Results of recent studies indicate that positive and negative molecules influence particular steps in the navigation of motor axons to their targets.
After chemically modifying the pore with 3-APTES, positively charged amine groups become attached to the membrane surface, which is favorable for negative molecules to enter the pore [31].
Finally, we assess the performance of the models trained with random negative molecules in a simulated target-prediction experiment, including the external data from a later version of ChEMBL (Table 5).
In this section, we investigate an approach to further improve performance of the models in the simulated target-prediction assessment by adding a sample of random negative molecules to the training set, labeling them all inactive.
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The IRF-5 (P68) functions as a dominant negative molecule through interacting with wildtype IRF-5, and leading to the inhibition of IRF-5 DNA binding and transactivation activity.
A highly conserved, cystein rich domain (CRD), presumed to bind Wnts, in the absence of a trans-membrane domain represents the structural requirement for a dominant negative molecule.
To assess the role of the endocytic machinery in DC, we first blocked endocytosis by expressing a Rab5 dominant negative molecule (Rab5DN) ubiquitously during embryogenesis.
IRF-5P68 phenotype results in a complete loss of its DNA-binding activity and functions as a dominant negative molecule through interacting with wild type IRF-5.
We were intrigued with a new member of the B7 family, B7-H3, as a potential negative molecule for T-cell activation in tumour immunity.
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