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These computed positive and negative module maximums were regarded as the peaks and valleys. .
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We divided the previously described ESR1 module (Desmedt et al, 2008) in two sub-modules, an 'ESR1-positive' and an 'ESR1-negative' module comprising, respectively, the genes whose expression correlates positively or negatively with that of ESR1.
Conversely, ESR1-negative-module genes showed significantly higher methylation levels in cluster II than in cluster I (Mann–Whitney test: p < 0.001; see Fig 2C and D and Table SIX of Supporting Information).
The negative feedback module is an analogue of the positive feedback module except that the response negatively regulates the production of the upstream element X∗.
Among them, genes GATA-1 and PU.1 form a core negative feedback module to regulate the genetic switching between the cell fate choices of HSCs.
(10) Negative power module: it is negative feedback helper effectors as opposite to positive feedback.
In the negative feedback module, the high diffusivity of the feedback element results in a greater spatial contrast of the response.
The presence of α-zearalenol and zearalenone in tissue affected by endometrial cancer was confirmed by the MS in the negative ionization module (Fig. 6).
In the case of this simple negative feedback module, an imperfect adaptive response is observed, where the response does not decrease to its original value, but to a value a little higher.
The negative feedback module is capable of exhibiting the property of adaptation - i.e. when a (homogeneous) step signal is applied to the module, a transient increase is observed in the response before it is reset at or close to its original value [ 44].
The equations governing the Negative Feedback module are given by (5) ∂ X ∗ ∂ t = (k sx S + k x ) X − k − x X ∗ − k yx X ∗ Y ∗ + D X ∂ 2 X ∗ ∂ θ 2 ∂ R ∗ ∂ t = (k xr X ∗ + k r ) R − k − r R ∗ + D R ∂ 2 R ∗ ∂ θ 2 ∂ Y ∗ ∂ t = (k ry R ∗ + k y ) Y − k − y Y ∗ + D Y ∂ 2 Y ∗ ∂ θ 2 Y is the intermediate feedback element as before.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com