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Last April marked a negative milestone, when more than half of all homes watching TV in prime time were watching basic cable -- the first time that had ever happened during an entire month of a regular broadcast season, according to Nielsen Media Research.
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"I always think of real estate cycles based on negative milestones," says Jonathan Miller, president of Miller Samuel, a New York residential real estate appraisal group.
What other important milestones – positive or negative – would you add?
"With its negative and positive, the election was a milestone," he said, though he acknowledged there had been violence and vote buying.
While findings regarding RA treatment with CCR5 inhibitors have thus far proven negative, these results still represent an important milestone in the development of target therapies for RA and other systemic autoimmune and inflammatory diseases.
Sixty years ago, Melanie Klein [ 14] referred to the capacity to experience simultaneous positive and negative emotions toward the same person as a developmental milestone and an indicator of emotional maturity.
The discovery of somatic mutations within the gene encoding calreticulin (CALR) in 2013 represented a major milestone in the molecular diagnosis of BCR-ABL negative myeloproliferative neoplasms (MPN).
Operational commissioning of ROBIN forms an important milestone in the Indian programme on the R&D on negative ion beams.
These observations provide a structural milestone for understanding multidrug resistance in pathogenic Gram-negative bacteria, and may also lead to the design of new antibacterial drugs.
Evidence suggests that even low levels of trace metal exposure, such as cadmium and lead, are linked to numerous negative health outcomes, including cognitive deficits and other delayed developmental milestones [ 34, 35, 37].
It's connotation with such negative effects makes it easy to forget that we can view menopause as something else: a milestone and an opportunity to stop and pamper ourselves.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com