Suggestions(1)
Exact(4)
The MelaFind outcomes were binary: positive (lesion should be considered for biopsy) and negative (lesion should be considered for later evaluation).
It is possible that many solitary focal infantile hepatic hemangiomas reported in the past are actually rapidly involuting congenital hemangiomas (RICHs), a GLUT1 negative lesion.
It was regarded as negative lesion when there was no change between CT images of at least the 5 month interval.
Whilst both tumours showed MCH class 1 staining, we note that the Bak negative lesion expressed actin whilst in the Bak positive lesion actin expression was much lower, suggesting a degree of heterogeneity between the tumour samples.
Similar(56)
Further, no reference standard for PET or CT negative lesions was used.
BLI negative lesions resulted not only in a decrease in sensitivity but obviously have also substantial contribution to non-optimal correlation of light signal and tumour size (Fig. 4).
In statistical analysis, the equivocal lesions were considered as negative lesions.
Sensitivity was calculated as true positive lesions/(false negative lesions + true positive lesions).
Specificity could not be calculated because of non-reporting of "true negative lesions".
The negative predictive value was calculated as the ratio of the number of galectin-3 negative benign lesions to the total number of galectin-3 negative lesions.
False negative lesions may also occur, primarily due to the spatial limits of resolution of the technique.
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