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American nuclear scientists began highly secretive discussions with their French counterparts that amounted to a game of 20 Questions, though in Washington-speak it was termed "negative guidance".
To get around such legal prohibitions, Washington came up with a system of "negative guidance," sometimes called "20 questions," as detailed in a 1989 article in Foreign Policy.
Of the 10 companies in the S.& P. 500 that have talked about the coming quarter, eight have provided negative guidance, according to Thomson Reuters.
So far, 17 companies have given what is known as negative guidance for future profit growth, and none have given positive guidance, a Thomson Reuters analyst, Greg Harrison, said.
Thomson Reuters recently calculated that 103 companies in the S&P 500 had issued negative guidance on profits compared with just nine that have been positive the worst ratio on record.
If such bellwethers as Wal-Mart offer negative guidance, the market may give back April's gains.
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The ratio of negative earnings guidance to positive for the second quarter is 3.3 to 1, the worst since 2008, Thomson Reuters data showed.
Professor Paul Ellis, a consultant oncologist at King's College, London, who worked on the drug trials, said in a statement issued by Roche that it "represents a significant advance in HER2-positive breast cancer, so for Nice to issue negative preliminary guidance is a huge blow.
He said: "Kadcyla represents a significant advance in HER2-positive breast cancer, so for NICE to issue negative preliminary guidance is a huge blow".
We propose a working model in which negative regulatory guidance clues from ephrin-A and ephrin-B must be overcome by positive clues from EphA4 and EphB1, present on the axon surface, in order for the axons to be selected for myelination.
Andy Brown at Panmure Gordon was also negative: While 2013 guidance remains in line with expectations, there are new clouds on the horizon.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com